...fertility tests, aids and vitamin supplements for couples planning a pregnancy...


   Home      FertilManPlus



babystart® FertilManplus™ is a nutritional supplement formulated to support sperm quality. Sperm quality relates to motility, count/concentration, morphology and volume.

babystart® FertilManplus™should be taken by men that have a known sperm quality problem or in support when, as a couple, a pregnancy is not occurring.

The formulation contains no herbals, only pure scientifically proven compounds, with known effects, giving
babystart® FertilManplus™ a high “quality” status.

Studies show that L-Carnitine and anti-oxidant supplementation, Glutathione in particular, can improve sperm quality, and possibly increase the chances of conception. There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm. Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.

Nutritional therapies and antioxidants that have proven beneficial in treating male infertility and improving sperm counts, sperm morphology and motility include:

L-Carnitine, L-Arginine, Zinc, Selenium, Vitamin A, B Vitamins, Vitamin C, Vitamin E, Glutathione, Coenzyme Q10 and Folic Acid, ALL of these are included in the formulation of the babystart® FertilManplus™ sperm supplement.
(Altern Med Rev2000;5(1):28-38)

 
 
 
 
babystart® FertilManplus™ has been formulated to provide a unique nutritional supplement for use by men when planning a pregnancy.
The ingredients have been carefully selected and are used in moderate safe levels according to EU standards. The formulation contains no herbals, only pure scientifically proven compounds with known effects giving 
babystart® FertilManplus™ a high “quality” status. Only those ingredients known to especially benefit fertility, conception and pregnancy are included. It has also been carefully formulated to help safeguard dietary requirements as soon as you start trying to conceive. This unique blend of vitamins, minerals, amino acids and anti-oxidants, are carefully chosen because of their properties beneficial to sperm production.

babystart® FertilManplus™ is blister packed to keep each tablet fresh by reducing exposure to the atmosphere. There are 120 tablets in each packet, take two tablets, twice per day as per the instructions. 

Manufactured in the UK to high GMP (Good Manufacturing Practice) quality standards.

Suitable for vegetarians.
 
Nutritional Information Average per day
(four tablets
per day)
% Recommended Daily Allowance Benefits
Fertility
Benefits
General Health
and Wellbeing
L-Carnitine 1200mg ----- yes yes
L-Arginine 280mg ----- yes yes
Vitamin C
  
180mg 225 yes yes
Magnesium 60mg 20 yes yes
L-Taurine 50mg ----- yes yes
Co Enzyme Q10 40mg ----- yes
Vitamin E 30mg 250 yes yes
Zinc 20mg 200 yes yes
Niacin (Vitamin B3) 18mg 112 yes  
Iron
  
15mg 107 yes
Vitamin B5 10mg 168 yes
Vitamin B6 10mg 714 yes
yes
Thiamin (Vitamin B1) 5.2mg 472 yes  
L-Glutathione 5mg ---- yes  
Riboflavin (Vitamin B2) 4.8mg 344 yes  
Copper 1mg 100 yes
Vitamin A (Beta carotene) 800ug ----- yes
Folic Acid
  
400ug
200
yes
yes
Selenium
160ug
292
yes
yes
Vitamin B12
60mcg
2400
yes
 
Vitamin D3
12mcg
240
yes
 
Ug = microgramme Mg = milligramme Energy, protein, fat and carbohydrate content negligible    

Ingredients:
L-Carnitine L-Tartrate, L-Arginine, Asorbic acid, Magnesium oxide, L-Taurine, Co-Enzyme Q10, DL-Alpha Tocopheryl, Zinc oxide, 
Nicotinamide, Ferrous fumarate, Calcium Pantothenate, Pyridoxine hydrochloride, Thamin hydrochloride, L-Glutathione, Riboflavin,
Cupric sulphate, Beta-carotene, Pteroylmonoglutamic acid, Sodium selenite, Cyanocobalamin, Cholecalciferol.
Anticaking agent: Magnesium stearate, Silicon dioxide. Bulk agent: Calcium carbonate, Microcrystalline cellulose. 
Coating: HPMC, Titanium dioxide, Microcrystalline cellulose, Stearic acid.
 
L-Carnitine: plays a key role in sperm energy metabolism. Many scientific studies have shown that carnitines play an important role in sperm function by affecting sperm motility, morphology, concentration and count. L-Carnitine can also help to protect sperm by reducing the influence of too many free radicals. (1-4)

L-Arginine: is a vital amino acid for sperm health, it is needed by the human body in large quantity and has been shown in numerous studies to improve quantity and motility of sperm. (5-6)

Zinc: is important in order to make the outer layer and tail of the sperm production of semen. Zinc effects an improvement in sperm cell density, a rise in the number of fast moving sperm cells, and an increase in the testosterone level which is crucial for spermatogenesis. Zinc is lost with each ejaculation, so an active sex life and a low zinc diet places a man at risk. Deficiency can cause impotence, infertility and low sperm count. Sub fertile men have been shown to have lower seminal levels of zinc than normal men. (7-9)

Copper: has a vital role as a free radical scavenger and helps prevent damage to cell structures. Zinc supplementation requires 1–2 mg of per day to prevent copper deficiency. Copper is an essential trace element present in the diet and in the human body. It is needed to absorb and utilize Iron.

Selenium: is a powerful antioxidant and is thought to stabiles the integrity of the sperm flagella. Too low a supply of selenium in the diet has been associated with poor sperm motility.  A male fertility dietary supplement that contains selenium may increase sperm motility. Research suggests a possible link between low levels of selenium in older parents and babies with Downs Syndrome. (10)

Vitamin B12: is involved in cell maturation and DNA synthesis. A deficiency of vitamin B12 in the nutrition is associated with decreased sperm count and motility, therefore, for enhanced sperm health vitamin B12 is essential. (11-12)

Vitamin A: is considered important for continual sperm production. (13-14)

Vitamin C: is an antioxidant present in the seminal plasma. It can increase sperm count and motility and decrease the risk of sperm damage. It can also help to remove lead from the body and is particularly important if the diet is low in fresh fruit and vegetables. Supplementation of vitamin C has reportedly improved the sperm quality of smokers. (15-17)

Vitamin E: is a fat-soluble antioxidant vitamin and helps to improve the overall health of sperm and can enhance the ability of the sperm cell to unite with the ovum. . Sperm can be damaged by free radicals and Vitamin E is an antioxidant that helps to reduce the number of free radicals. Deficiency can cause damage to reproductive tissues. (18-20)

Glutathione: is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa. The glutathione enzymes play a central role in the defense against oxidative damage in human sperm. A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress. (21-24)

Coenzyme Q10:
 acts as an antioxidant and energy-promoting agent and is thought to stablise the integrity of the sperm flagella. Studies have demonstrated a correlation between Coenzyme Q10 levels and sperm health. (25-26)

Folic Acid: concentrations have been shown to be higher in seminal fluid than plasma in men. It is vital for cell development and cell division (blood production), as well as for nerve metabolism. It is also so involved with the coronary system. Studies suggest that supplementation of Folic Acid along with Zinc improves sperm health in both sub fertile and fertile men. 

Pantonthenic Acid: Vitamin B5 can be helpful in reversing testicular torsion and carries the ability of backing up reduced glutathione levels.

Vitamin D3: assists in the production of sex hormones in men. A recent study found that vitamin D3 levels in men correspond directly to the quality of sperm they produce. Men with higher levels of vitamin D in their blood had higher quality sperm, that were faster and better swimmers, as well as better at penetrating the egg. Our studies suggest that vitamin D supplementation might increase testosterone levels, another factor which affects male fertility. (27)

Vitamin B1: Thiamin (vitamin B5) and Riboflavin (vitamin B2) help the body produce energy and affect enzymes that influence the muscles, nerves and heart. (28-29)

FOOD SUPPLEMENT: This product is not a substitute for a healthy balanced diet. Anyone taking anticoagulants (blood thinners), should not take these capsules except on the advice of a doctor. Also professional advice should be sought before using these too, should there be a history of food intolerance or allergies.

References:

(1) Costa M et al. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility.
Andrologia. 1994 May-Jun;26(3):155-9

(2) Lenzi A, Lombardo F, Gandini L, Dondero F. Metabolism and action of L-carnitine: its possible role in sperm tail function.
Arch Ital Urol Nefrol Androl. 1992 Jun;64(2):187-96.

(3) Menchini-Fabris GF et al. Free L-carnitine in human semen: its variability in different andrologic pathologies. Fertil Steril. 1984 Aug;42(2):263-7.

(4) Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic (23) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19

(5) Scibona M et al. L-arginine and male infertility. Minerva Urol Nefrol. 1994 Dec;46(4):251-3.

(6) Schachter A et al. Treatment of oligospermia with the amino acid arginine. Int J Gynaecol Obstet. 1973 Sep;11(5):206-9.

(7) Lewin, A et al. Studies on arginine in human semen. 3. The influences of several drugs on male infertility.
Bull Osaka Med Sch. 1967 Oct;13(2):90-100.

(8) Tikkiwal M et al. Effect of zinc administration on seminal zinc and fertility of oligospermic males.
Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4

(9) Takihara H, Cosentino MJ, Cockett AT. Zinc sulfate therapy for infertile male with or without varicocelectomy. Urology. 1987 Jun;29(6):638-41

(10) Madding CI, Jacob M, Ramsay VP, Sokol RZ. Serum and semen zinc levels in normozoospermic and oligozoospermic men.
Ann Nutr Metab. 1986;30(4):213-8.

(11) Moslemi, M et al. Selenium – Vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate.
Int J Gen Med 2011;4:99-104

(12) Moriyama H, et al. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia.
Hinyokika Kiyo. 1987 Jan;33(1):151-6.

(13) Hermes, R et al. Improvement of male fertility by long-term beta carotene supplementation in white rhinoceros. Institute for zoo and wildlife research, 2003.

(14) Almbro, M. et al. Effects of Vitamin E and beta-carotene on sperm competitiveness. Ecology Letters doi: 10.1111/j.1461-0248.2011.01653.x

(15) Sandler, B et al. The treatment of oligospermia with stilbestrol and vitamin B. Fertil Steril. 1961 Sep-Oct;12:469-73.

(16) C G Fraga, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
Proc Natl Acad Sci U S A. 1991 December 15; 88(24): 11003–11006.

(17) Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality.
J Clin Biochem Nutr. 2009 Sep;45(2):144-9.

(18) Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers.
Fertil Steril. 1992 Nov;58(5)1034-9

(19) Kessopoulou E et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertil Steril. 1995 Oct;64(4):825-31

(20) Geva E et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program.
Fertil Steril. 1996 Sep;66(3):430-4.

(21) Aitken RJ et al. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl. 1989 May-Jun;10(3):214-20.

(22) Lenzi, A., F. Culasso, L. Gandini, F. Lombardo, and F. Dondero. "Placebo-controlled, Double-blind, Cross-over Trial of Glutathione Therapy in Male Infertility." Hum. Reprod. 8.10 (1993): 1657-62. Print.

(23) Shamsi, M.B., S. Venkatesh, M. Tanwar, P. Talwar, R.K. Sharma, A. Dhawan, R. Kumar, N.P. Gupta, N. Malhotra, and N. Singh. "DNA Integrity and Semen Quality in Men with Low Seminal Antioxidant Levels." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 665.1-2 (2009): 29-36. Print.

(24) Lenzi, A., F. Lombardo, L. Gandini, F. Culasso, and F. Dondero. "Glutathione Therapy for Male Infertility." Arch Androl 29.1 (1992): 65-8. Print.

(25) Lenzi A et al. Glutathione therapy for male infertility. Arch Androl. 1992 Jul-Aug;29(1):65-8.

(26) Lewin A, Lavon H. The effect of coenzyme Q10 on sperm motility and function. Mol Aspects Med 1997; 18: S213-19

(27) Pilz S et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011 Mar;43(3):223-5.

(28) Fleming JC et al. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2.
Mol Genet Metab. 2003 Sep-Oct;80(1-2):234-41.

(29) Oishi K, et al. Male infertility due to germ cell apoptosis in mice lacking the thiamin carrier, Tht1. A new insight into the critical role of thiamin in spermatogenesis. Dev Biol. 2004 Feb 15;266(2):299-309.
 
                             Copyright © 2009 - 14. Babystart Ltd. All rights reserved.